"This is still the gold standard against which all other medicinal chemistry books must be judged. It is content rich, yet attempts to relate the discipline to modern clinical practice. It is comprehensive and accessible, and an excellent resource for students as well as professionals seeking to update their knowledge. The addition of the clinical significance sections alone justifies replacing the previous edition."
- Doody Enterprises, Inc. (June 2012)
- Michael R. Borenstein, PhD(Temple University School of Pharmacy)